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- Best seller Failing Up: How to Take Risks, Aim Higher, and Never Stop Learning (International
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#27 G?O N?P G?O T? - Phim Gia Dinh Vi?t 2018online can and and
Most avian influenza viruses do not replicate efficiently in human cells. This is partly due to the low activity of the RNA polymerase of avian influenza viruses in mammalian cells. Accordingly, viral ribonucleoprotein RNP reconstitution assays show that a viral polymerase containing PB2 E has impaired activity in mammalian cells compared to a viral polymerase that contains PB2 K, characteristic of mammalian-adapted influenza viruses. We found that PB2 E polymerase restriction in mammalian cells is independent of NP expression but is dependent on the length of the viral RNA template. In addition, restriction of PB2 E polymerase was overcome by mutations specific to the viral RNA template promoter sequence. Consequently, we propose that PB2 E affects recruitment of the viral RNA promoter by the viral polymerase in mammalian cells.
25 Thang Mu?i Hai Th? Hai, 31/12/ GMT+7 T?p phim G?o n?p g?o t? phat song t?i 24/12 tren kenh HTV2, xoay quanh chuy?n tinh yeu d?m.
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The RNA polymerase of influenza A virus is a host range determinant and virulence factor. In particular, the PB2 subunit of the RNA polymerase has been implicated as a crucial factor that affects cell tropism as well as virulence in animal models. These findings suggest that host factors associating with the PB2 protein may play an important role during viral replication. In order to identify host factors that associate with the PB2 protein, we purified recombinant PB2 from transiently transfected mammalian cells and identified copurifying host proteins by mass spectrometry. Some of these binding partners associate with each other, suggesting that PB2 might interact with these proteins in multimeric complexes. PB2 proteins from various influenza virus subtypes and origins can associate with CCT.
Best seller Failing Up: How to Take Risks, Aim Higher, and Never Stop Learning (International
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