When is the best time to take levothyroxine

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Effects of evening vs morning levothyroxine intake: a randomized double-blind crossover trial.

when is the best time to take levothyroxine

Recall Issued for Thyroid Medication

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Flowchart of the study, showing disposition of patients from screening to study completion. Consecutive patients with primary hypothyroidism who visited our clinics were assessed for study eligibility. Study exclusion criteria were gastrointestinal disorder, thyroid carcinoma, and pregnancy. Thyroid hormone levels after 6 and 12 weeks of morning or bedtime intake of levothyroxine sodium. To convert thyrotropin level to micrograms per liter, multiply by 1. Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If you have no conflicts of interest, check "No potential conflicts of interest" in the box below.

There is consensus that levothyroxine should be taken in the morning on an empty stomach. A pilot study showed that levothyroxine intake at bedtime significantly decreased thyrotropin levels and increased free thyroxine and total triiodothyronine levels. To date, no large randomized trial investigating the best time of levothyroxine intake, including quality-of-life evaluation, has been performed. METHODS: To ascertain if levothyroxine intake at bedtime instead of in the morning improves thyroid hormone levels, a randomized double-blind crossover trial was performed between April 1, , and November 30, , among consecutive patients with primary hypothyroidism at Maasstad Hospital Rotterdam in the Netherlands. Patients were instructed during 6 months to take 1 capsule in the morning and 1 capsule at bedtime one containing levothyroxine and the other a placebo , with a switch after 3 months. Primary outcome measures were thyroid hormone levels; secondary outcome measures were creatinine and lipid levels, body mass index, heart rate, and quality of life. Compared with morning intake, direct treatment effects when levothyroxine was taken at bedtime were a decrease in thyrotropin level of 1.

Back to Medicines A to Z. Levothyroxine is a medicine used to treat an underactive thyroid gland hypothyroidism. The thyroid gland makes thyroid hormone which helps to control energy levels and growth. Levothyroxine is taken to replace the missing thyroid hormone. Levothyroxine is only available on prescription.

The absorption of levothyroxine in the gut is decreased when taking the hormone at the same time as calcium, iron and some foods and other drugs. Because of this, patients are usually instructed to take levothyroxine on an empty stomach minutes before food intake to avoid erratic absorption of the hormone. For many patients, this means first thing in the morning before breakfast. This is often difficult for many patients, especially those on multiple medications. This study was performed to see if patients can take their levothyroxine with food in the morning and not have to wait minutes. Serum thyrotropin levels following levothyroxine administration at breakfast.

Drug information provided by: IBM Micromedex. This medicine will need to be taken for the rest of your life or your child's life. Do not stop taking this medicine or change your dose without first checking with your doctor. It may take several weeks before you start to notice that your symptoms are better. It is best to take this medicine on an empty stomach.

Managing an underactive thyroid gland requires you to take a thyroid drug every single day. Consistency is key, meaning it's important to take your thyroid pill at the same time daily. Most are told to take their medication first thing in the morning, rather than before they go to sleep. But the truth is that either time of day works, although one time may better suit your lifestyle. In addition, there is some research suggesting that taking your dose at bedtime may allow for better thyroid hormone absorption. Discuss when to take your thyroid medication with your doctor. These pros and cons can help guide your conversation.

Levothyroxine—Is Morning Still the Best Time to Take It?


It has long been known that many foods and medications — including calcium supplements, soy, and iron—interfere with the absorption of oral levothyroxine in the body. Levothyroxine is one of the most commonly prescribed medications in the US. Treatment for hypothyroid must be timed to avoid milk. Results showed that the TT4 concentrations were significantly lower when levothyroxine was taken at the same time as the milk as compared to levothyroxine alone. The researchers believe that both the calcium content of the milk and the presence of protein might directly interfere with the proper and full absorption of levothyroxine, complicating the management of hypothyroid.



Is There a Best Time to Take Your Thyroid Medication?



5 thoughts on “When is the best time to take levothyroxine

  1. Effects of evening vs morning levothyroxine intake: a randomized double-blind crossover trial.

  2. If you have hypothyroid, the timing of your levothyroxine will make all are typically instructed to take levothyroxine an hour before breakfast.

  3. Despite levothyroxine being the treatment of choice for those with an underactive thyroid there are few guidelines in term of timing.

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